Peptide Based Supramolecular Polymer and Receptor

Nandi, Sujay kumar (2020) Peptide Based Supramolecular Polymer and Receptor. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Sujay kumar Nandi (13IP030)) 13IP030.pdf - Submitted Version Restricted to Repository staff only Download (18MB)

Abstract

The thesis deals with the development of simple peptide or peptidomimetic based colourimetric as well as fluorescent probes for the selective detection of various biologically and environmentally relevant analytes, including fluoride, slow death poison element arsenic, hydrazine, the most essential part of life; water, etc. Selective detection of environmentally hazardous acid and lives threaten nitro-explosives are also focused in the thesis. We have further used the supramolecular polymer formation concept to fabricate the probe for the detection of different hazardous as well as biologically and environmentally relevant analytes. Chapter 1 provides a general overview of the thesis and its background. General discussion and classification of different self-assembly systems are discussed in this chapter. The basic criteria of a sensor and its classification are too discussed in this chapter. This chapter deals with the different aspects of supramolecular polymer formation. A peptide-based conducting hydrogel for the detection of acid (HCl) was investigated in Chapter 2. The conductive nature of the hydrogel-based sensor was used for the online HCl gas sensor. Chapter 3 deals with the detection of nitro-explosive TNP by a robust tripeptide. The probe shows high selectivity towards TNP over other different nitro-explosives. A paper strip and fingerprint-based device was fabricated for the in-field TNP sensor. The sensor can able to selectively detect TNP in the solution state, solid-state, and gaseous state and even in an aqueous medium. Colourimetric cascade detection of fluoride and moisture was discussed in Chapter 4. Paper strip based in-field instant detection of fluoride and moisture was also discussed here. In this chapter, we have able to developed a device for re-writable and security devices. Selective detection (colourimetric and spectroscopic), quantification, and removal of As(III) through the formation of a metallo-supramolecular polymer were discussed in Chapter 5. The concentration of unknown As(III) in an unknown water sample can be measured by our design calibration curve. Hydrogen bonded supramolecular polymer formation and chemodosimetric detection of hydrazine by NDI based peptide molecule among different other electron-rich amines was clearly explained in detail in Chapter 6. A clear-cut fluorescence change from green to light yellow to dark orange was observed. We have unambiguously shown the formation of NDI based linear oligomers and cyclic nanorim.

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