Design, Synthesis and Evaluation of Functional Amphiphilic Polymers for Therapeutic Applications

Venu, Parvathy (2022) Design, Synthesis and Evaluation of Functional Amphiphilic Polymers for Therapeutic Applications. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Parvathy Venu ((15RS032)) 15RS032_DCS.pdf - Submitted Version Restricted to Repository staff only Download (6MB)

Abstract

The main objective of this thesis was to design the functional self-assembled amphiphilic polymers which can be used for therapeutic applications. Self-assembled nanomaterials are useful for a wide variety of applications from fundamental to applied research fields, with salient effects in biomedical and environmental sciences. Various biodegradable polymers can be reliably arranged to form spontaneous self-arranged stimuli-responsive systems according to certain circumstances. Here, in my research tenure I have targeted to synthesize five different classes of polymers including homopolymer, block copolymer and random copolymer based on biodegradable polymer backbones and explore the self-assembly nature for making it beneficial for drug delivery applications. In the thesis work, selection of biodegradable and biocompatible polymers, highly efficient anti-cancer drug, pendant functionalities, control of the size and shape of assembled structures, etc are given more significance to produce smart nanocarrier for drug delivery purpose. In general, considering all the advantages of self-assembled polymeric nanoparticles, it can perform as smart nanocarrier for delivering anti-cancer drug to the specific affected cellular site.

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