Design, Synthesis and Evaluation of Functional Amphiphilic Polymers for Therapeutic Applications

Venu, Parvathy (2022) Design, Synthesis and Evaluation of Functional Amphiphilic Polymers for Therapeutic Applications. PhD thesis, Indian Institute of Science Education and Research Kolkata.

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The main objective of this thesis was to design the functional self-assembled amphiphilic polymers which can be used for therapeutic applications. Self-assembled nanomaterials are useful for a wide variety of applications from fundamental to applied research fields, with salient effects in biomedical and environmental sciences. Various biodegradable polymers can be reliably arranged to form spontaneous self-arranged stimuli-responsive systems according to certain circumstances. Here, in my research tenure I have targeted to synthesize five different classes of polymers including homopolymer, block copolymer and random copolymer based on biodegradable polymer backbones and explore the self-assembly nature for making it beneficial for drug delivery applications. In the thesis work, selection of biodegradable and biocompatible polymers, highly efficient anti-cancer drug, pendant functionalities, control of the size and shape of assembled structures, etc are given more significance to produce smart nanocarrier for drug delivery purpose. In general, considering all the advantages of self-assembled polymeric nanoparticles, it can perform as smart nanocarrier for delivering anti-cancer drug to the specific affected cellular site.

Item Type: Thesis (PhD)
Additional Information: Supervisor: Prof.. Raja Shunmugam
Uncontrolled Keywords: Drug Carriers; Functional Amphiphilic Polymers; Functional Amphiphilic Polymers-Design; Functional Amphiphilic Polymers-Synthesis; Functional Amphiphilic Polymers-Evaluation; Polymers-Therapeutic Applications; Self Assembled Polymers
Subjects: Q Science > QD Chemistry
Divisions: Department of Chemical Sciences
Depositing User: IISER Kolkata Librarian
Date Deposited: 31 Mar 2022 10:24
Last Modified: 31 Mar 2022 10:25

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