Design and Synthesis of Polymer-Based Chemo dosimeter for Sensing Anionic and Cationic Pollutant

Singha, Jyotirlata (2022) Design and Synthesis of Polymer-Based Chemo dosimeter for Sensing Anionic and Cationic Pollutant. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Jyotirlata Singha (15RS061)) 15RS061.pdf - Submitted Version Restricted to Repository staff only Download (8MB)

Abstract

The development of Norbornene-based and acrylic acid-based polymeric materials for sensing toxic anions and heavy metals is the goal of my research work. The advantages of polymeric probes over monomeric sensors in terms of detection limit, response time, and water solubility have been discussed with proper experimental evidence. The effect of pollution originating from heavy metals such as F⁻, Hg²⁺, NaOCl, H₂S has been discussed in detail. In chapter 1: here 2,4-dinitrophenylhydrazine based colorimetric monomeric and polymeric sensors were designed, prepared, and analyze, which investigated as selective, ratio metric chromogenic sensor under the naked eye for F⁻ ion detection. In naked eye solution of sensors changes intense deep red color from light yellow color. The mechanism of H-bonding interaction was proven by ¹H NMR and ¹⁹F NMR titration spectra analysis. All the sensor molecules have good real-life applications. In chapter 2: an efficient new sensor Acpmono and Acppoly were designed and developed for efficient and selective mercury quantification at ppm-level. Sensor molecules have a good real-life application, in-field detection of Hg²⁺ was monitored by preparation of paper strip using polymeric sensor Acppoly, cellular level detection was proven by internalization of Acpmono and Acppoly into live HeLa cell. All the above electronic response is by making a complex via displacement of core H-atom of porphyrin moiety. In chapter 3: For this purpose, monomeric (Nor-oh) and polymeric (Norp-PEG-oh) novel fluorescent sensors have been designed for the specific, sensitive, and unique probes that exhibit distinctive features such as excellent resistance to photobleaching, a high fluorescence brightness, high selectivity. Both the sensor Nor-oh and Norp-PEG-oh can monitor NaOCl from a real water sample, in-field detection of NaOCl has been monitored via preparation of paper strip using Norp-PEG-oh. All the above electronic response was via the ICT process. In chapter 4: The monomeric sensor NNAPM and polymeric sensor NNAP-peg-P for H₂S detection were developed and well-characterized. Sensor structure was revealed an extremely fast, selective, and highly sensitive yellowish “turn-on” emission response in presence of H₂S. All the molecule has shown drastic deep yellow fluorescence turn-on response in presence of analyte H₂S. Preparation of paper strip confirms the infield application of the polymeric sensor. All the sensor molecules have good real-life applications. Cell viability is very good, also can detect H₂S from the cellular level (proved by internalization in HeLa cell) Response of sensor by PET off mode towards analyte.

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