Synthesis and Self-Assembly of Peptide Mimetics

Samanta, Rahul (2022) Synthesis and Self-Assembly of Peptide Mimetics. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS dissertation of Rahul Samanta (16MS019)) 16MS019_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (3MB)

Abstract

This thesis entitled “Synthesis and Self-Assembly of Peptide Mimetics” represents the synthesis, characterization, conformational analysis, and aggregation studies in physical domains. The chapter 3 entitled “Synthesis and assembly of phthalimide protected dipeptides” represents synthesis of dipeptides containing N-phthaloylamino acids done using solution phase methods. This is followed by their characterization by NMR, FTIR and Mass spectroscopy. Further, their morphology was studied by Field Emission Scanning Electron Microscopy. The dipeptides self-assembled to form fibriller morphology. The chapter 4 entitled “Synthesis and optical properties of urea-coumarin luminophores” represents the synthesis of the urea-coumarin luminophore. In the first step methyl ester protected coumarin-3-carboxylic acid was obtained by reaction of salicylaldehyde with dimethyl malonate in piperidine at 80°C. The nitration of resultant compound by mixed acid at 0°C provides 6-nitro-coumarin-3-carboxylic acid methyl ester. Reduction of 6-nitro-coumarin-3- carboxylic acid methyl esterwith Sn/ HCl generates the 6-amino-coumarin-3-carboxylic acid methyl ester which on microwave irradiation with urea provides the desired urea-coumarin-3- carboxylic acid methyl ester luminophore. The absorption and emission spectroscopic studies suggest that the intermolecular interactions play a crucial role for the luminophore compound. POM images exhibit flake like morphology for the luminophore compound.

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