The Correlation of Tissue Properties with Myosin Cable Formation during Germband Retraction in Drosophila

Rai, Hrishika (2022) The Correlation of Tissue Properties with Myosin Cable Formation during Germband Retraction in Drosophila. Masters thesis, Indian Institute of Science Education and Research Kolkata.

[img] Text (MS dissertation of Hrishika Rai (16MS113))
16MS113_Thesis_file.pdf - Submitted Version
Restricted to Repository staff only

Download (3MB)
Official URL:


Actomyosin contractility is a driver of changes and cell shapes and results in large tissue movements. The contractile stresses generated by actomyosin require spatial and temporal regulation. A number of chemical mechanisms have been studied that regulate myosin accumulation. These signals can drive patterned accumulation of myosin in the tissue. In addition to chemical signals, mechanical signaling regulates myosin through. However, the mechanosenstive response of myosin is based on forces in one part of the tissue that influence another part in the same tissue. In this study, the focus is on the interaction of two different tissue where forces from one tissue influence myosin regulation in a distinct but attached tissue. Hence, the study studies the stage of GBR in Drosophila where two different tissue are involved and forces from amnioserosa drive myosin accumulation in the epidermis. While forces act as inducers of myosin, the study also takes into account properties of tissue that are permissive to myosin accumulation. These tissue properties include alignment of cell contacts and the cell shape index. Although, these tissue configurations do not correlate with myosin accumulation, the study raises questions on tissue properties that lead to variability of myosin signals.

Item Type: Thesis (Masters)
Additional Information: Supervisor: Prof. Tony Harris (University of Toronto); Co-supervisor: Dr. Bidisha Sinha
Uncontrolled Keywords: Actomyosin Contractility; Drosophila; Germband Retraction; Myosin Cable Formation; Pattern Formation; Tissue Properties
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Department of Biological Sciences
Depositing User: IISER Kolkata Librarian
Date Deposited: 30 Aug 2022 11:27
Last Modified: 30 Aug 2022 11:27

Actions (login required)

View Item View Item