Computational Investigations of Membrane Influence on Protein Behavior

Mahapatra, Anshuman Jaysingh (2022) Computational Investigations of Membrane Influence on Protein Behavior. Masters thesis, Indian Institute of Science Education and Research Kolkata.

[img] Text (MS dissertation of Mahapatra Anshuman Jaysingh (17MS054))
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Membrane-protein simulations have become increasingly popular throughout the last decade, owing to advancements in computing power and algorithmic optimisations related to force fields. Membrane-protein simulations are now being routinely utilised as supporting evidence for experimental discoveries, aiding structural elucidation methods as well as elucidating protein-associated dynamical processes. Unrelated to experimental data, these simulations, by their own virtue, have also proven to be instrumental in investigating larger-scale processes like protein sorting, membrane-protein interactions, and more. In this work, we will be exploring two systems at the absolute endpoints of the spectrum of membrane-protein interactions, bacteriorhodopsin and alpha-synuclein, and try to elucidate the emergent properties that arise from membrane protein interactions.

Item Type: Thesis (Masters)
Additional Information: Supervisor: Dr. Neelanjana Sengupta
Uncontrolled Keywords: Alpha-Synuclein; Bacteriorhodopsin; Coarse-Grained Molecular Dynamics; Hydrophobic Mismatch; Intrinsically Disordered Proteins; Membrane Curvature; Membrane-Protein Simulations
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Divisions: Department of Biological Sciences
Depositing User: IISER Kolkata Librarian
Date Deposited: 21 Apr 2023 11:30
Last Modified: 21 Apr 2023 11:30

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