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Self-Assembly of Synthetic Peptides: Biological and Material Aspects

Kumar, Pankaj (2011) Self-Assembly of Synthetic Peptides: Biological and Material Aspects. Masters thesis, Indian Institute of Science Education and Research, Kolkata.

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    It represents the synthesis, characterization, conformational analyses and self-association of designed peptides using proteinus and/or synthetic amino acids. Chapter 1 describes the objective of this thesis. Chapter 2 includes the detailed description of synthetic procedures, experimental strategies and reagents that are employed to perform the whole work, embodied in this thesis. Chapter 3 describes the synthesis and conformational analysis of a dipeptide bearing sequence similarity with Aβ18-19 (the fragment 18-19 of the amyloid β-peptide A42). The dipeptide adopts an extended backbone conformation. But, the peptide finally forms a supramolecular β-sheet structure at higher order assembly. The structures of these reported peptides in the solid state were determined by FTIR and morphologies of these peptides were studied by atomic force microscopy.

    Item Type: Thesis (Masters)
    Additional Information: Under the Supervision of Dr. Debasish Haldar
    Uncontrolled Keywords: Synthetic Peptides; Self Assembly
    Subjects: Q Science > QD Chemistry
    Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 03 Jun 2011 13:52
    Last Modified: 27 May 2013 14:16
    URI: http://eprints.iiserkol.ac.in/id/eprint/13

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