Non-Equilibrium Models inspired by RNA-Protein Specific Binding and Recognition

Sriram, Vedanth (2022) Non-Equilibrium Models inspired by RNA-Protein Specific Binding and Recognition. Masters thesis, Indian Institute of Science Education and Research Kolkata.

[img] Text (MS dissertation of Vedanth Sriram (17MS078))
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RNA-Protein interactions play a vital role in Biology today. Not only are they central to numerous cellular functions such as transcription, translation and viral replication but their interactions may also have played a role in primordial life forms during the ’RNA World’. Earlier, due to limited structural information, studies elucidating exact RNA-Protein interaction pathways were limited. More recently, however, using the power of molecular dynamics and other simulation methods, more information about these pathways; both from a thermodynamic and kinetic perspective is available. This thesis aims to model the RNA-protein binding pathway inspired by the TAR-TAT system, which is common in viruses such as the Human Immunodeficiency Virus (HIV). Using tools from non-equilibrium statistical mechanics, we develop a minimal physical model to understand if and how domain-domain fluctuation anti-correlations could help direct specific recognition and binding processes in such RNA-Protein systems.

Item Type: Thesis (Masters)
Additional Information: Supervisor: Prof. P.K. Mohanty; Co-Supervisor: Dr. Susmita Roy
Uncontrolled Keywords: Non-Equilibrium Models; Non-Equilibrium Statistical Mechanics; RNA-Protein Interactions; RNA Structure
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH301 Biology
Divisions: Department of Chemical Sciences
Depositing User: IISER Kolkata Librarian
Date Deposited: 07 Jun 2023 11:02
Last Modified: 07 Jun 2023 11:02

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