Synthesis of Glyco-polypeptide for Antibacterial Applications

Dash, Surya Swaroop (2022) Synthesis of Glyco-polypeptide for Antibacterial Applications. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS dissertation of Surya Swaroop Dash (17MS113)) 17MS113_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (1MB)

Abstract

It is anticipated that by 2050, the antimicrobial resistance will be one of the greatest threats to human health that will lead to more deaths than cancer. The new generation antimicrobial agents (both broad spectrum and selective) that do not induce AMR are urgently required. Antimicrobial peptide (AMP) is one of widely studied class of peptide in these past few years, due to their unique membrane- active antimicrobial mechanism and broad-spectrum antimicrobial activity. Despite many attempts, AMP has not shown any significant development in its clinical trials. Green chemistry encourages to employ sugar and saccharide resources to biomolecule for sustainable approach. Generally, bacteria use carbohydrates for biological processes like metabolism and physiological process like biological information transmission through specific interaction with protein. The conjugated carbohydrate unit with a biopolymer will provide a specific binding affinity towards the bacterial cells. Taking this work forward, our group envision the design and synthesis of Novel monosaccharide/ disaccharide functionalized statistical copolymers which can specifically target towards bacteria in vivo. The above biopolymer will be characterized by NMR spectroscopy, IR spectroscopy, CD spectroscopy and zeta protentional measureme.

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