Organophotocatalyzed Trifluoromethylation/Thiolation and C(sp³)–H Bond Functionalization

Ghosh, Krishna Gopal (2023) Organophotocatalyzed Trifluoromethylation/Thiolation and C(sp³)–H Bond Functionalization. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Krishna Gopal Ghosh (15RS014)) 15RS014.pdf - Submitted Version Restricted to Repository staff only Download (15MB)

Abstract

Photo redox catalysis has been one of the fastest-growing interests in organic chemistry research for the last few decades. In this process, a well-engineered photo catalyst simply empowering light energy triggers a chemical redox process to furnish tedious chemical conversion catalytically. The journey of photocatalysis was initiated with a few well-known metal complexes and organic dyes to replace the expensive transition metal catalysis in an eco-friendly manner. Its unique radical pathway, energy efficiency, and exceptionally mild requirements to furnish the reaction made it famous in a decade. With intensive research, many new organic-photocatalysts have been developed to cut short the expenses and environmental hazards of using transition metal complexes like Ir, Ru, etc. And also opens up the catalytic process's variable reactivity and tunability with plenty of accessible options. In this thesis, I elaborately documented the implementation of organo-photoredox catalysis to perform trifluoromethylation/thiolation and C(sp³)–H bond functionalizations. The enhanced biomedical advantages of small fluorinated molecules in drug discovery and the agrochemical industry indulge my research intrigue in finding new photocatalytic processes for trifluoromethylation/thiolation chemistry. The C(sp³)–H bond functionalization has been a leading research topic from the last century. C(sp³)–H bond functionalizations is an often-used handy tool for the organic chemist to furnish lengthy synthesis in an ese, with more quantitative, steps-atom economical, and quicker conversion. But the significant shortfall of this strategy is the usage of expensive transition metals, high reaction temperature, and requirements of selective and customized ligands for the targeted C−H bond functionalizations. A significant research effort for this thesis has been spent developing a photocatalytic strategy for C(sp³)–H bond functionalizations to eliminate these disadvantages above.

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