Towards the Chemical Synthesis of the Tetrasaccharide Repeating unit of the O-antigen from Salmonella enterica O56

Biswas, Bidipta (2023) Towards the Chemical Synthesis of the Tetrasaccharide Repeating unit of the O-antigen from Salmonella enterica O56. Masters thesis, Indian Institute of Science education and Research Kolkata.

Text (MS dissertation of Bidipta Biswas (18MS094)) Thesis_18MS094.pdf - Submitted Version Restricted to Repository staff only Download (9MB)

Abstract

Chapter 1: This chapter introduces the reader with the genesis and significance of carbohydrates in various life processes, their classifications on the basis of structural aspects and application in modern-day therapeutics. Chapter 2: In this chapter, mechanism of glycosylation and use of different donors/acceptors and promoter systems for efficient stereo- and regioselectivity are discussed with emphasis on glycosyl halides, thioglycosides and glycosyl trichloroacetimidates. Chapter 3: This chapter illustrates the chemical adventure towards the chemical synthesis of the 4-amino-4,6-dideoxy-D-glucose containing tetrasaccharide repeating unit of the O-antigen from Salmonella enterica O56. Preparations of different rationally protected monosaccharide derivatives and the glycosylation reactions are elaborated in detail. The judicious planning to deal with the remaining challenge is discussed as future work.

Actions (login required)

View Item