Regioselective Synthesis and Electrochemical Sulfonylation of Pyrazoles

Dubey, Abhishek (2021) Regioselective Synthesis and Electrochemical Sulfonylation of Pyrazoles. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS Dissertation of Abhishek Dubey (16MS038)) 16MS038_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (3MB)

Abstract

Pyrazoles are essential compounds prevailing in synthetic drugs and have an extensive scope of biological activities like anti-fungal, anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anticonvulsant, etc. Sulfones groups containing organic compounds are another significant scaffold found in many biologically active molecules and organic materials and are extensively used as biopharmaceutical agents and solvents in several chemical reactions. Hence, the synthesis of substituted pyrazole has therefore dragged our considerable interest. Although many synthetic methods are available, we have exploited electrochemical organic synthesis as electrochemical synthesis offers a mild, green, and atom efficient route to selective oxidation and reduction transformation using electrons as the reactant, thus avoiding harsh and costly chemicals. Therefore, Effective and environment-friendly organic synthesis can be achieved by catalytic oxidation and reduction, and the process is highly selective in the presence of acid and base-sensitive substrate. It also offers less energy cost, functional group tolerance, chemo-selectivity, and effortless scalability. Hence, we developed a greener and environment-friendly method to synthesise substituted pyrazoles and their derivatives by electrochemical activation of sulfonyl hydrazide.

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