Pal, Arindam Kumar (2025) Molecular Self-Assembly of Asparagine & Lysine-based Amphiphiles: Biomaterials, Malaria Infection Mechanisms, and Antibacterial Applications. Masters thesis, Indian Institute of Science Education and Research Kolkata.
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Text (MS Dissertation of Arindam Kumar Pal (20MS052))
20MS052_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (2MB) |
Abstract
Malaria and antibiotic resistance remain critical global health challenges, necessitating novel therapeutic strategies. This study explores the role of asparagine-rich environments in the Plasmodium sp. heme detoxification process. For doing so, we have designed, synthesised & characterized a library of asparagine-based amphiphiles. Further, screened & found out the best hydrogel among them. Next, we have modified a hemozoin formation assay to prove the role of asparagine in the parasite food vacuole. Subsequently, we have synthesised lysine-phenylalanine amphiphiles and investigated the self-assembly & anti-bacterial property against E. coli. This work establishes asparagine-mediated hemozoin formation as a druggable target and highlights lysine-based amphiphiles as promising antimicrobial scaffolds, bridging molecular self-assembly with therapeutic innovation.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Supervisor: Prof. Pradip Kumar Tarafdar |
| Uncontrolled Keywords: | Malaria Infection Mechanisms, Antibacterial Applications, Lysine-based Amphiphiles, Antibiotic Resistance |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Department of Chemical Sciences |
| Depositing User: | IISER Kolkata Librarian |
| Date Deposited: | 07 Jan 2026 10:14 |
| Last Modified: | 07 Jan 2026 10:14 |
| URI: | http://eprints.iiserkol.ac.in/id/eprint/1989 |
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