CATALYTIC VESICLES CAN GROW AND DIVIDE OUT OF EQUILIBRIUM

Das, Swagata (2025) CATALYTIC VESICLES CAN GROW AND DIVIDE OUT OF EQUILIBRIUM. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS Dissertation of Swagata Das (20MS058)) 20MS058_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (1MB)

Abstract

Metabolically active protocell of extant biology has the capability to grow and divide under nonequilibrium conditions by leveraging chemical reactions. Herein, we show a ternary system, which featured a pool of biologically-derived molecular entities comprising an activated ester-functionalized lipid amphiphile, a fatty aldehyde and a simple amino acid like histidine, that can exploit multiple feedback loops coupled via its inherent catalytic proficiency to demonstrate growth and division under non-equilibrium conditions. This out-of-equilibrium behavior contribute to our growing understanding of the chemical emergence of protocellular life on early earth.

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