Luminescent Transition Metal-Polypyridyl Complexes for Microenvironment-Responsive Theranostics: From Imaging to Therapeutic Application

Borah, Sakira Tabassum (2026) Luminescent Transition Metal-Polypyridyl Complexes for Microenvironment-Responsive Theranostics: From Imaging to Therapeutic Application. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Sakira Tabassum Borah (19RS026),) 19RS026.pdf - Submitted Version Restricted to Repository staff only Download (18MB)

Abstract

This thesis explores the design, synthesis, and functional evaluation of luminescent transition metal complexes engineered for microenvironment-responsive photodynamic therapy (PDT) and bioimaging applications. It delves into the evolving domain of emissive Iridium(III) and Platinum(II) complexes, examining their photophysical and electrochemical behaviour while exploring their theranostic potential. The thesis contains five chapters that explore into different aspects of these complexes. Chapter 01 introduces the concept of microenvironment-adaptive transition metal complexes, emphasizing their tunable photophysical properties and responsiveness to tumor-specific biochemical cues. Chapter 02 focuses on phenanthrene-substituted cyclometalated Ir(III) complexes, highlighting their capability as image-guided agents for multimodal photodynamic inactivation of cancer cells. Chapter 03 investigates photoresponsive cyclometalated Ir(III) complexes exhibiting intrinsic oxidase-like activity and their ability to induce glutathione depletion and redox imbalance for enhanced therapeutic efficiency. Chapter 04 presents β-cyclodextrin-encapsulated Pt(II)-based nanoparticles that serve as efficient photosensitizers for PDT and potent inhibitors of the NF-kB signaling pathway in glioblastoma models. Finally, Chapter 05 describes aqua-friendly Ir-Pt bimetallic complexes featuring pH-responsive aggregation-induced emission enhancement for selective imaging of bacterial cells in aqueous environments. Collectively, these studies advance the understanding and application of photoactive metal-based systems as multifunctional platforms for targeted therapy, redox modulation, and real-time bioimaging.

Actions (login required)

View Item