An Organophotocatalytic Route to Access Functionalized 1,2-Benzothiazine Dioxides

V J, Aliya (2025) An Organophotocatalytic Route to Access Functionalized 1,2-Benzothiazine Dioxides. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS Dissertation of Aliya V J (20MS134)) 20MS134_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (4MB)

Abstract

A transition metal-free photoredox strategy for the efficient synthesis of difluoromethyl-substituted 1,2-benzothiazine dioxide derivatives has been developed. This method employs radical addition to alkenes followed by a cascade cyclization, affording the desired products in yields of up to 67%. Mechanistic studies revealed that the catalytic cycle is initiated by oxidative quenching of the organic photocatalyst 4DPAIPN. Importantly, the transformation proceeds under redox-neutral conditions, without the need for transition metals, stoichiometric oxidants, or external additives

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