Metal-free Electrosynthesis of 1,3-Dihydro-Oxazines through TEMPO Mediated Multi-component Coupling

Chandra, Sourav (2025) Metal-free Electrosynthesis of 1,3-Dihydro-Oxazines through TEMPO Mediated Multi-component Coupling. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS Dissertation of Sourav Chandra (23MP009)) 23MP009_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (6MB)

Abstract

A convenient one-pot synthesis of 1,3-dihydro-oxazines has been achieved via TEMPO-mediated multicomponent coupling, following a transition metal-free approach. Herein, our methodology proceeds through an electrochemical oxidative pathway, which also offers a super-stoichiometric oxidant-free reaction. Notably, our plan proceeds through a Mannich reaction following an annulation step. This multicomponent coupling reaction gives a broad range of substrate scope. Moreover, this electro-synthetic methodology provides a convenient and operationally simple route to access these valuable heterocycles, effectively bypassing traditional harsh reaction parameters such as elevated temperatures and the inclusion of transition metal species.

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