Synthesis of Novel Diindolyl methane and Peptide Chemosensors for Molecular Recognition of Selective Anions

Biswas, Soma (2025) Synthesis of Novel Diindolyl methane and Peptide Chemosensors for Molecular Recognition of Selective Anions. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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Abstract

The search for the novel synthetic molecular receptors for the anion recognition and sensing is an important research area in the field of supramolecular chemistry. However, designing the molecular anion receptors is particularly challenging. The process of anion recognition is highly selective and in living systems the Hydrogen-bonding (HB) interactions available from various amino acids of the protein molecules are used to recognize different anions. Recent researches reveal that suitable indole derivatives have the potential to sense selective anions under controlled environment. This thesis work discusses the synthesis of novel diindolyl methane derivatives, di(1H-indol- 3-yl)methane (1), 3,3’-(Phenylmethylene)bis(1H-indole) (2) and 2-(Di(1H-indol-3- yl)methyl)phenol (3) and a peptide methyl (E)-(2-cyano-3-phenylacryloyl)-L-tryptophanate (4). The diindolyl methane derivatives and the peptide were characterized by common spectroscopies techniques like, UV-vis FTIR, 1H & 13C NMR. These molecules were used recognize inorganic phosphate anion and picric acid (Trinitro phenol, TNP). The anion recognition was studied by UV-vis and fluorescence spectroscopies.

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