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Investigation of Heterocycle Based Complexes and Aromatic Nitrosoureas as Anticancer Agents

Sarkar, Amrita (2016) Investigation of Heterocycle Based Complexes and Aromatic Nitrosoureas as Anticancer Agents. PhD thesis, Indian Institute of Science Education and Research Kolkata.

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    Abstract

    Cancer represents a class of disease characterized by uncontrolled the division of abnormal cells that may invade other tissues. The term “chemotherapy” encompasses the chemicals to treat disease. The modern era of chemotherapy against cancer began with nitrogen mustards, the bioisoteric analogue of warfare agent sulfur mustard. Over the time the development of more effective chemotherapeutic agents has became a prime endeavor. This thesis work mainly involves towards the synthesis, characterization and cytotoxicity studies and investigation of probable pathways of actions of certain newly designed anticancer agents having either alkylation / cross linking capability or planar moieties to intercalate DNA.

    Item Type: Thesis (PhD)
    Additional Information: Supervisor: Dr. Arindam Mukherjee
    Uncontrolled Keywords: Anion Sensing; Anthraimidazoledione Derivatives; Anticancer Agents; Aromatic N-nitrosoureas; Aromatic Nitrosoureas; Atmospheric CO2 Fixation; Cancer; Chemotherapeutics; Chemotherapy;DNA Binding; Heterocycle Based Complexes; Metal complexes; Methionine Conjugated Heteroscorpionate Bispyrazole Ligands; Nitric oxide Release; N-nitrosocarbamates; Pyridine Based Oxazolidinone;
    Subjects: Q Science > QD Chemistry
    Divisions: Department of Chemical Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 12 May 2016 13:05
    Last Modified: 12 May 2016 13:05
    URI: http://eprints.iiserkol.ac.in/id/eprint/275

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