Patra, Diptendu (2015) Norbornene Based Random Copolymer for Site Specific Cancer Therapy. Masters thesis, Indian Institute of Science Education and Research Kolkata.
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PDF (MS dissertation of Diptendu Patra (13IP026))
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Abstract
The present work aimed at looking at the use and advantage of the polymers in cancer drug delivery. All the monomers were successfully synthesized and characterised by ¹H & ¹³C NMR spectroscopy. The formation of the copolymer was characterised by GPC (PMMA standards). The amphiphilicity of the copolymer was characterised by DLS. This random co-polymer is amphiphilic in nature because the DOXI attached Norbornene segment behaves as a hydrophobic part where as the PEG attached segment is hydrophilic in nature which makes it easily soluble in water and form aggregates, which is confirmed by SEM. This completely water soluble stimuli responsive prodrug is expected to show efficient anti cancer activity towards breast cancer cell line (MCF-7).
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Supervisor: Dr. Raja Shummugam |
| Uncontrolled Keywords: | Anticancer Drug; Cancer Therapy; Drug Delivery; Norbornene; Polymer; Random Copolymer; Site Specific Cancer Therapy |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Department of Chemical Sciences |
| Depositing User: | IISER Kolkata Librarian |
| Date Deposited: | 21 Jun 2016 05:25 |
| Last Modified: | 21 Jun 2016 05:26 |
| URI: | http://eprints.iiserkol.ac.in/id/eprint/329 |
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