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Norbornene Based Random Copolymer for Site Specific Cancer Therapy

Patra, Diptendu (2015) Norbornene Based Random Copolymer for Site Specific Cancer Therapy. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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    Abstract

    The present work aimed at looking at the use and advantage of the polymers in cancer drug delivery. All the monomers were successfully synthesized and characterised by ¹H & ¹³C NMR spectroscopy. The formation of the copolymer was characterised by GPC (PMMA standards). The amphiphilicity of the copolymer was characterised by DLS. This random co-polymer is amphiphilic in nature because the DOXI attached Norbornene segment behaves as a hydrophobic part where as the PEG attached segment is hydrophilic in nature which makes it easily soluble in water and form aggregates, which is confirmed by SEM. This completely water soluble stimuli responsive prodrug is expected to show efficient anti cancer activity towards breast cancer cell line (MCF-7).

    Item Type: Thesis (Masters)
    Additional Information: Supervisor: Dr. Raja Shummugam
    Uncontrolled Keywords: Anticancer Drug; Cancer Therapy; Drug Delivery; Norbornene; Polymer; Random Copolymer; Site Specific Cancer Therapy
    Subjects: Q Science > QD Chemistry
    Divisions: Department of Chemical Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 21 Jun 2016 10:55
    Last Modified: 21 Jun 2016 10:56
    URI: http://eprints.iiserkol.ac.in/id/eprint/329

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