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Exploring Drug Delivery Mechanisms Using Micelle, Polymer & MNPs Drug Release Employing Optical, pH & Magnetic Tweezers

Singhal, Satyam (2013) Exploring Drug Delivery Mechanisms Using Micelle, Polymer & MNPs Drug Release Employing Optical, pH & Magnetic Tweezers. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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    Abstract

    The project involves designing a drug delivery mechanism for the delivery of anti-cancer drugs using a composite micelle encapsulating drug for targeted drug delivery and release using appropriately designed optical tweezers. The idea is to employ the micelle containing the molybdate so as to enable its trapping by an optical tweezer. All the sample solutions with varying concentrations of molybdate are prepared and the stability observed. The DLS and zeta pot. Measurements give a fair idea of the trend in the stability. The drug is carbohydrate based. The HeLa cells are used for in-vitro confirmation of the principle. AFM studies further establish the presence of molybdate and its location in the micelle. The action of optical tweezers is expected to ensure easy maneavouring of the micellar drug and specific release at the desired location.

    Item Type: Thesis (Masters)
    Additional Information: Supervisor: Dr. Soumyajit Roy
    Uncontrolled Keywords: Drug Delivery Mechanisms; Micelle; Drug Release; Magnetic Tweezers; Drug Delivery Agent; Drug Delivery Pathway; Anticancer Drugs; Polymer Micelles; Nanomedicine
    Subjects: Q Science > QD Chemistry
    Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 02 May 2013 08:16
    Last Modified: 12 Nov 2014 09:45
    URI: http://eprints.iiserkol.ac.in/id/eprint/38

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