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Fluctuation Study of Plasma Membrane Spheres

Alex, Amal (2016) Fluctuation Study of Plasma Membrane Spheres. Masters thesis, Indian Institute of Science Education Research Kolkata.

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    Abstract

    The cell membrane is a highly dynamic system and membrane tension physically regulates many cellular processes. To understand the underlying non-active physical mechanisms, studies on cells need to be complemented with studies on model membrane systems. Plasma membrane spheres (PMS) are model membrane systems that lack cortical actin network and have lipid composition close to that of cells. We use Reflection Interference Microscopy to map membrane fluctuations in PMS and compare it with cell data. We have observed reduced temporal fluctuations and reduced spatial heterogeneity in PMS compared to cells. We think the reduced spatial heterogeneity in PMS is due to the absence of internal cytoskeletal structures.

    Item Type: Thesis (Masters)
    Additional Information: Supervisor: Dr. Bidisha Sinha
    Uncontrolled Keywords: Biological Membranes; Fluctuation Study; Membrane; Membrane Fluctuations; Membrane Tension; Plasma Membrane; Plasma Membrane Spheres; RICM; Reflection Interference Contrast Microscopy
    Subjects: Q Science > QH Natural history > QH301 Biology
    Divisions: Department of Biological Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 10 Aug 2016 16:18
    Last Modified: 10 Aug 2016 16:19
    URI: http://eprints.iiserkol.ac.in/id/eprint/402

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