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Guanosine Derivatives for the Selective G-quadruplex Recognition and Synthetic Ion Channel Formation

Kumar, Y. Pavan (2016) Guanosine Derivatives for the Selective G-quadruplex Recognition and Synthetic Ion Channel Formation. PhD thesis, Indian Institute of Science Education and Research Kolkata.

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    Abstract

    This thesis “Guanosine Derivatives for the Selective G-quadruplex Recognition and Synthetic Ion Channel Formation” describes synthesis of mono- and di-guanosine derivatives using a modular synthetic approach using click chemistry. This thesis comprises two chapters. Chapter 1 describes design and synthesis of guanosine derivatives linked with fluorescent probes (dansyl and anthracene) using Click-Chemistry for the detection of G-quadruplex structures. Chapter 2 describes synthesis of diguanosine derivatives using Click-Chemistry which can self-assemble to form synthetic ion channels across a biological membrane.

    Item Type: Thesis (PhD)
    Additional Information: Supervisor: Dr. Jyotirmayee Dash and Dr. Balaram Mukhopadhyay
    Uncontrolled Keywords: Biological Membrane; Click Chemistry; Di-guanosine Derivatives; Fluorescent Probes; Guanosine Derivatives; Modular Synthetic Approach; Mono-guanosine Derivatives; Synthetic Ion Channel
    Subjects: Q Science > QD Chemistry
    Divisions: Department of Chemical Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 29 Aug 2016 15:39
    Last Modified: 29 Aug 2016 15:40
    URI: http://eprints.iiserkol.ac.in/id/eprint/494

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