Multifractal Models and Inverse Light Scattering Methods for Biological Tissue Characterization and Diagnosis

Das, Nandan Kumar (2017) Multifractal Models and Inverse Light Scattering Methods for Biological Tissue Characterization and Diagnosis. PhD thesis, Indian Institute of Science Education and Research Kolkata.

PDF (PhD thesis of Nandan Kumar Das (11RS042)) Thesis_NandanKrDas.pdf - Submitted Version Restricted to Repository staff only Download (4MB)

Abstract

The thesis is dedicated towards development of novel light scattering based approaches for the extraction and quantification of morphological changes at the micron / sub-micron length scales of biological tissues. Specifically, multifractal models combined with elastic scattering spectroscopic (both polarization resolved and polarization-blind) measurements are explored for the quantification of ultra-structural information on tissue, which are otherwise hidden in conventional light scattering measurements. The efficacy of such multifractal approaches have been tested and applied on ex-vivo tissues in the context of tissue characterization and diagnosis, with early indications showing considerable promise of the developed approaches and warranting further exploration. In the context of in-vivo biophotonics applications for precancer detection, the free space optical systems (light scattering spectroscopic and Mueller matrix spectroscopic systems) can be improved using all optical fiber based systems equipped with automated analysis algorithm. In our laboratory, we have already initiated development of such prototype system that can be deployed in clinics. We have initially developed an optical fiber probe assisted smart phone based device for in-vivo applications of the developed multifractal approaches. The system has also been used for initial clinical trials on patients having different stages of oral cancers.

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