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Peptide Based Smart Materials: Structure and Application

Maji, Krishnendu (2018) Peptide Based Smart Materials: Structure and Application. PhD thesis, Indian Institute of Science Education and Research Kolkata.

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    Smart materials are designer synthetic materials having one or more functionalities which can be significantly changed in a controlled fashion by exploitation of external stimuli, such as temperature, moisture, stress, pH, sonication, light, electric or magnetic fields. Smart materials are highly interesting for their potential applications in chemistry, biology, medicine as well as material sciences. So, the design and synthesis of smart materials are now hot topics of recent research. This thesis entitled Peptide-Based Smart Materials: Structure and Application represents the synthesis, characterization, conformational analyses, self-association and application of designed peptides using proteinous and/or noncoded amino acids. The thesis describes the synthesis and characterization of a series of peptide mimetic compounds containing leucine, tyrosine, and malonic acid which self-assemble through various noncovalent interactions. This thesis contains the description of the structure-function relationship of hybrid supramolecular materials by a novel method based on fluorescence spectroscopic Mueller matrix measurements and inverse analysis. Design and fabrication of a new self-cleaning hybrid molecular material containing polyhedral oligomeric silsesquioxane (POSS) and diphenylalanine have been described here. This thesis contains the design and synthesis of a triazole-based amino acid which has a broad spectrum antibacterial activity against gram positive, gram negative and pathogenic bacteria. The thesis covers the design and synthesis of a series of trizole containing dipeptides which show significant anti Leishmaniasis activity.

    Item Type: Thesis (PhD)
    Additional Information: Supervisor: Dr. Debasish Haldar
    Uncontrolled Keywords: Anti Leishmaniasis Agent; Click Amino Acid; Diphenylalanine; Fluorescence Spectroscopy; Peptide-Based Smart Materials; Peptides Self Assembly; Proteins; Self-Assembled Peptides; Smart Materials; Spider Silk
    Subjects: Q Science > QD Chemistry
    Divisions: Department of Chemical Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 26 Oct 2018 10:23
    Last Modified: 26 Oct 2018 10:23
    URI: http://eprints.iiserkol.ac.in/id/eprint/621

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