Anisotropic Gold Nanoparticles for Modulating Cross-β Assemblies

Yazhini, A. Darshana (2018) Anisotropic Gold Nanoparticles for Modulating Cross-β Assemblies. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of A. Darshana Yazhini (13MS100)) 13MS100.pdf - Submitted Version Restricted to Repository staff only Download (41MB)

Abstract

Soft nanostructures such as peptide nanotubes can act as cargo carriers by binding to small molecules as well as charged nanoparticles. My thesis study aims towards understanding of the disassembly of these soft nanostructures, specifically Cross-β amyloid peptide self assemblies by melting them using NIR induced heating of Gold Nanorods (GNRs). The principle of NIR induced melting can be used to modulate the morphology of the nanotubes in such a way that they can act as delivery systems by releasing cargo. One of the implications of such a modulation is targeted drug delivery and disassembly of the amyloid fibrils responsible for Alzheimer’s Disease. This study only covers the successful synthesis of the constituents that make up the system. Heating, melting and disassembly studies have not been carried out in this part.

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