Chemoselective Reduction of Imines to Amines by a Novel Co(II) Phenalenyl Complex using Polymethylhydrosiloxane(PMHS)

Rahul, K. H. (2018) Chemoselective Reduction of Imines to Amines by a Novel Co(II) Phenalenyl Complex using Polymethylhydrosiloxane(PMHS). Masters thesis, Indian Institute of Science Education and Research Kolkata.

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Abstract

This thesis consists of synthesizing new phenalenyl based ligands, a novel Cobalt(II) phenalenyl complex and checking the catalytic activity of the complex by doing reduction of imines to secondary amines in a chemoselective fashion by means of hydrosilylation. In this work, PMHS is used as the hydride source. In a sustainable and economic point of view, PMHS is an interesting alternative hydrosilane as it is an inexpensive residue from silicon industry. The thesis begins by giving a brief introduction about the importance of phenalenyl moeity and its metal complexes in designing organometallic catalysts for various homogeneous organic transformation. Since the novel Co(II)-catalyst shows activity towards imine reduction, challenges of imine reduction, it's limitations, advantages of our current strategy and uniqueness of hydrosilylation for reduction reactions are outlined. Even though we haven’t done any stochiometric reactions to prove the mechanistic path, I have tried my best to provide a possible mechanistic cycle at the end. The motivation for doing this project and our objectives are delineated. Finally, our experimental results and future directions of the work are described.

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