Biswas, Ashik (2018) Cyanomethylation of α-amino acid derivatives using C(sp³)–H bond activation. Masters thesis, Indian Institute of Science Education and Research Kolkata.
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PDF (MS dissertation of Ashik Biswas (13MS069))
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Abstract
Transition metal catalysed C–H bond activation is a well established and crucial transformation in the organic synthesis. In this study, we developed a new method for β-cyanomethylation of α-amino acids via palladium catalysed aminoquinoline (AQ) directed β-C(sp³)–H bond activation with insitu generated iodoacetonitrile (ICH2CN) from chloroacetonitrile (ClCH2CN) and NaI. Unlike previous report where cyanomethylation of C(sp³)–H bond is limited to alanine derivative only, our protocol works well with different amino acids and carboxylic acids derivatives with excellent diastereoselectivity and good chemical yields.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Supervisor: Dr. Devarajulu Sureshkumar |
| Uncontrolled Keywords: | Alpha-Amino Acids; Beta-cyanomethylation; Carboxylic Acids; Organic Synthesis; Transition Metal |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Department of Chemical Sciences |
| Depositing User: | IISER Kolkata Librarian |
| Date Deposited: | 04 Dec 2018 05:40 |
| Last Modified: | 04 Dec 2018 05:40 |
| URI: | http://eprints.iiserkol.ac.in/id/eprint/724 |
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