Silk Sericin Based Hybrid Macroporous Scaffolds Using Ice-Templating Method

Ajith, Krishnaveni (2018) Silk Sericin Based Hybrid Macroporous Scaffolds Using Ice-Templating Method. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of Krishnaveni Ajith (13MS101)) 13MS101.pdf - Submitted Version Restricted to Repository staff only Download (2MB)

Abstract

The potential of Sericin (a protein in natural Silk), as a biomaterial has been brought out through this project. Since Sericin has a long history of being discarded as a waste material in Silk industries, efforts were made to utilize this waste protein in an advantageous way so that it can significantly contribute to lessen the effects of environmental pollution caused due to the high biological oxygen demand of the protein. Hybrid scaffolds have been successfully prepared using Sericin, Mesoporous Nanoparticles (MSNs) and Glutaraldehdye. The organic and inorganic content were varied to make scaffolds and optimized the conditions. The circular dichroism experiments of Sericin protein were carried out and studies made by varying pH. The prepared scaffolds were characterised by SEM for surface morphological studies. Drug encapsulation and release studies of hybrid scaffolds were also performed using MSN as a control. Additionally, FT-IR studies of MSN, Sericin and the hybrid scaffolds has been carried out. All the results demonstrate that the Sericin-MSN-Glu hybrid scaffolds have great scope in the field of biomedical applications, especially in tissue engineering and further studies on this topic will definitely symbolize them as promising carriers of hydrophobic/hydrophilic dyes and contribute to drug delivery applications.

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