Conformational Studies of Gramicidin Inspired Alternating LD Peptides

Kumar, Pratik (2013) Conformational Studies of Gramicidin Inspired Alternating LD Peptides. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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The conformational properties of polypeptides are of great interest to structural biologists and chemists for their functional significance. Several peptide antibiotics, like Gramicidin, Valinomycin are having D-amino acids in the sequence. Gramicidins are linear pentadecapeptide antibiotics produced by the soil bacterium Bacillus brevis during sporulation. It consists of alternating L- and D-amino acids, in contrast to most natural peptides or proteins, which are made of L-amino acids. Gramicidin acts as an ion channel in bacterial cell membrane allowing monovalent cations (K+, Na+) travel from extracellular environment to the cytoplasm. It forms beta helical structure inside lipid bilayer and dimerizes to span the whole membrane. This thesis attempts to explore the conformational properties of gramicidin-inspired alternating L- and D-amino acids containing polypeptides.

Item Type: Thesis (Masters)
Additional Information: Supervisor: Dr. Rituparna Sinha Roy
Uncontrolled Keywords: Conformational Properties; Polypeptides; Gramicidins; Amino Acid
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: IISER Kolkata Librarian
Date Deposited: 27 May 2013 10:00
Last Modified: 12 Nov 2014 06:53

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