Understanding the role of Hinge3 in border cell migration during Drosophila oogenesis

Kant, Shashi (2019) Understanding the role of Hinge3 in border cell migration during Drosophila oogenesis. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of Shashi Kant (14MS141)) 14MS141.pdf - Submitted Version Restricted to Repository staff only Download (4MB)

Abstract

During solid tumor cell metastasis, there are some group of cancer cells cluster which migrate from affected to healthy organs by the process of collective cell Unfortunately, we do not have much understanding of this collective cell migration of cancer cell during metastasis. Every year millions of people die because of cancer metastasis. Therefore, understanding collective cell migration scientific research. There are some signaling pathways like JAK pathway, which are unregulated during cancer cell metastasis has also been seen to modulate border cell cluster migration during useful model system to study collective cell migration in the metazoans. a complex process where several genes are known to regulate border cell migration by different pathways. Hinge3 is a transcriptional co activator that is expressed in border cell clusters. My thesis suggests that Hinge3 regulates border cell migration. As the Hinge3 deficient border cell clusters exhibit lesser number of cells and lower levels of F actin, my probably regulates the border cell specification and protrusion dynamics.

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