Spike Frequency Adaptation

Augustine, Vineet (2013) Spike Frequency Adaptation. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS Dissertation of Vineet Augustine (08MS32)) Vineet_Augustine-08MS32-MSThesis.pdf - Submitted Version Restricted to Repository staff only Download (1MB)

Abstract

Spike frequency adaptation is the collective name for the processes that bring down the frequency of rhythmic tonic firing of action potentials. This sometimes leads to the termination of spiking and giving rise to quiescent cells. Spike frequency adaptation is quite a common phenomenon. A number of models have been postulated for spike frequency adaptation. Benda et al came up with a universal model for spike frequency adaptation using a single adaptation current. M-Type Currents, mAHP Currents and Slow Recovery from Inactivation are responsible for spike frequency adaptation. However, the times scales for adaptation for these currents is quite different. Hence, a model for spike frequency adaptation with two adapting currents is in order. Additionaly, in retinal adaptation it is understood how the ganglion cell responds to mean and variance of visual stimuli. But its response to higher order statistics in stimuli is a grey area. An attempt is made to numerically study adaptation to the variance of the input current. Furthermore, the Pinsky-Rinzel model to simulate a bursting neuron is coded.

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