Palladium Catalyzed Remote C-H Arylation and Oxidative Olefination of 2-Aminoalkylpyrimidine

Das, Animesh (2019) Palladium Catalyzed Remote C-H Arylation and Oxidative Olefination of 2-Aminoalkylpyrimidine. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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Introduction of an alkylamine to an electron deficient pyrimidine ring helped to achieve site selective functionalization under Palladium catalysis. A straightforward strategy was developed for remote arylation and olefination at C5-position of the N-(tert-butyl)pyrimidin- 2-amine core with easily available aryl halides and alkenes respectively. Similar selectivity was also achieved when oxidative arylation was done with polyfluoroarenes. The transformation was accomplished with a wide scope and functional group tolerance.

Item Type: Thesis (Masters)
Additional Information: Supervisor: Dr. Biplab Maji
Uncontrolled Keywords: 2-Aminoalkylpyrimidine; Palladium; Oxidative Olefination; Remote C-H Arylation
Subjects: Q Science > QD Chemistry
Divisions: Department of Chemical Sciences
Depositing User: IISER Kolkata Librarian
Date Deposited: 18 Feb 2020 07:20
Last Modified: 18 Feb 2020 07:20

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