Rpy, Rajat (2019) Hemozoin Inhibition by Ions : A New Approach to Fight The Malaria. Masters thesis, Indian Institute of Science Education and Research Kolkata.
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PDF (MS dissertation of Rajat Roy (14MS048))
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Abstract
Malaria is a ife-threatening disease caused by Plasmodium protozoa and the RBCs are functioned as the main target molecule for their survival inside human body where they transform heme into hemozoin, termed as malarial pigment, to reduce the toxicity towards the parasites. It is well established that inhibition of heme to hemozoin transformation can lead us to the recovery of the diseases and many of the available drugs are believed to be working via that pathway. However, the emerging drug resistance power of the malarial protozoa lead us to explore new approaches to inhibit the hemozoin inhibition. Using an invitro assay we have shown that some physiological ions (phosphate, chloride) significantly inhibit the hemozoin formation. We further developed an effective assay for heme to hemozoin transformation at higher pH (~4.5) mimicking the physiological condition and investigated the role of lipid membrane. We established that lipid component of vesicle greatly modulates the hemozoin formation.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Supervisor: Dr. Pradip Kumar Tarafdar |
| Uncontrolled Keywords: | Antimalarial Drugs; Hemozoin; Hemozoin Inhibition; Ions; Malaria |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Department of Chemical Sciences |
| Depositing User: | IISER Kolkata Librarian |
| Date Deposited: | 19 Feb 2020 10:14 |
| Last Modified: | 19 Feb 2020 10:15 |
| URI: | http://eprints.iiserkol.ac.in/id/eprint/973 |
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