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Synthesis of Bioactive Oligosacchrides, Development of Methodologies and Synthesis of Metal-Carbohydrate Complexes for Catalysis

Verma, Prashant Ranjan (2013) Synthesis of Bioactive Oligosacchrides, Development of Methodologies and Synthesis of Metal-Carbohydrate Complexes for Catalysis. PhD thesis, Indian Institute of Science Education and Research Kolkata.

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    Abstract

    After illustrating the biological significance of carbohydrates, its use as therapeutics and the emergence of glycomics, the present work reviews different techniques of glycosidic bond formation considering different types of donors and promoters as well as some special techniques developed for the stereoselective formation of glycosidic linkages. Later it describes the total synthesis of tetra- and a trisaccharide related to the repeating unit of the Oantigen from Providencia rustigianii O34. Then it moves to deal with the synthesis and catalytic use of Carbohydrate derived thiosemicarbazone and semicarbazone Palladium complexes. After that it describes the total synthesis of a tetrasaccharide from Azospirillum lipoferum SR65. It then provides a detailed account of the development of the methodologies for carbohydrate protecting group manipulation by using H2SO4-silica. It consist the Selective hydrolysis of benzylidene and isopropylidene group using H2SO4-Silica in presence of acid labile p-methoxybenzyl group. Later it presents a detailed of synthesis of tetrasaccharide related to Shigella boydii type O16

    Item Type: Thesis (PhD)
    Additional Information: Supervisor: Dr. Balaram Mukhopadhyay
    Uncontrolled Keywords: Bioactive Oligosacchrides; Catalysis; Metal-Carbohydrate Complexes; Oligosaccharide Synthesis; Tetrasaccharide; Trisaccharide
    Subjects: Q Science > QD Chemistry
    Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 13 Nov 2014 16:24
    Last Modified: 13 Nov 2014 16:26
    URI: http://eprints.iiserkol.ac.in/id/eprint/115

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