A Code for Automated High Throughput Screening and its Demonstration in Screening of Metal Analytes for a Novel near IR Chemosensor

Roy, Saswata (2014) A Code for Automated High Throughput Screening and its Demonstration in Screening of Metal Analytes for a Novel near IR Chemosensor. Masters thesis, Indian Institute of Science Education and Research Kolkata.

PDF (MS dissertation of Saswata Roy) Saswata_Roy.pdf - Submitted Version Restricted to Repository staff only Download (11MB)

Abstract

An algorithm has been designed to cater to a quantitative comparison between two chemosensors. It essentially pinpoints the wavelength at which a Poincare section need to be drawn in order to have a lower dimensional representation of that data, which is more convenient to work with. This algorithm also helps to amplify small changes which go unnoticed when left to human judgment. It also helps identify an isosbestic point with high precision. To test the efficacy of the code, a new chemosensor was developed. This 1,8-diaminonaphthlene based chemosensor has methionine attached to the amines to act as receptors for metal ions. Its basic spectroscopic studies were conducted and a near-IR fluorescence response was detected for the addition of Cu(II) salts in the system.

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