Effect of anti-inflammatory homeopathic medicines on the migration of the mammalian breast cancer cell line

Basu, Rupsa (2025) Effect of anti-inflammatory homeopathic medicines on the migration of the mammalian breast cancer cell line. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS Dissertation of Rupsa Basu (20MS008)) 20MS008_Thesis_file.pdf Restricted to Repository staff only Download (3MB)

Abstract

Despite significant advancements in cancer therapy over the decades, cancer remains largely incurable at advanced stages, and treatments are often financially inaccessible for many people worldwide. Treatment strategies vary depending on the stage and type of cancer, but one of the most critical and life-threatening stages is metastasis. This paper focuses on targeting metastasis—the stage responsible for cancer spreading to distant organs—using affordable, traditionally used natural medicines. Metastasis is primarily driven by the Epithelial to Mesenchymal Transition (EMT), a cellular process characterized by the loss of epithelial traits and the acquisition of mesenchymal features, enabling cells to migrate and invade. A key contributor to EMT is inflammation, which not only activates genes involved in EMT but also supports a pro-migratory environment through the recruitment of immune cells and tissue-repair mechanisms. In this context, chronic inflammation plays a pivotal role in sustaining the conditions necessary for cancer cell dissemination. To mitigate the impact of chronic inflammation, the use of anti-inflammatory agents is essential. Homeopathic medicines, known for their anti-inflammatory and immunomodulatory properties, have long been used to treat a variety of inflammatory and allergic conditions, even before the advent of modern pharmaceuticals. Furthermore, several reports suggest that homeopathy may serve as a complementary approach in cancer therapy. In this study, we explore the potential of selected anti-inflammatory homeopathic medicines in inhibiting the migration of breast cancer cells, thereby targeting a critical step in the metastatic

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