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Studies on the Effect of Copper Nanoparticles and Copper Complex on DNA Molecules, Bacteria and Cancer Cells: Implications in Antibacterial and Anticancer Therapy

Gregor, P. J. (2014) Studies on the Effect of Copper Nanoparticles and Copper Complex on DNA Molecules, Bacteria and Cancer Cells: Implications in Antibacterial and Anticancer Therapy. PhD thesis, Indian Institute of Science Education and Research (IISER) Kolkata.

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    Abstract

    This study has identified novel DNA degrading copper nanoparticles with a superior bactericidal activity and anticancer activity than the ionic copper. This study also had shed light into their mechanism of action too. ACCC was found to be a better anticancer agent than the anti caner drug, cisplatin. This is the first report on the biological activity of an abnormal N heterocyclic carbene copper complex. Further studies needs to be carried out to understand more about its therapeutic potential. SCA is a promising candidate with its antibacterial and anticancer activity. To understand its potential fully, surface modification to increase its solubility is required.

    Item Type: Thesis (PhD)
    Additional Information: Supervisor: Dr. Tapas Kumar Sengupta
    Uncontrolled Keywords: Antibacterial Therapy; Anticancer Therapy; Bacteria; Cancer Cells; Copper Complex; Copper Nanoparticles; DNA Molecules;
    Subjects: Q Science > QH Natural history > QH301 Biology
    Divisions: Department of Chemical Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 07 Aug 2015 11:04
    Last Modified: 07 Aug 2015 14:38
    URI: http://eprints.iiserkol.ac.in/id/eprint/250

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