Studies on the Effect of Copper Nanoparticles and Copper Complex on DNA Molecules, Bacteria and Cancer Cells: Implications in Antibacterial and Anticancer Therapy

Gregor, P. J. (2014) Studies on the Effect of Copper Nanoparticles and Copper Complex on DNA Molecules, Bacteria and Cancer Cells: Implications in Antibacterial and Anticancer Therapy. PhD thesis, Indian Institute of Science Education and Research (IISER) Kolkata.

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Abstract

This study has identified novel DNA degrading copper nanoparticles with a superior bactericidal activity and anticancer activity than the ionic copper. This study also had shed light into their mechanism of action too. ACCC was found to be a better anticancer agent than the anti caner drug, cisplatin. This is the first report on the biological activity of an abnormal N heterocyclic carbene copper complex. Further studies needs to be carried out to understand more about its therapeutic potential. SCA is a promising candidate with its antibacterial and anticancer activity. To understand its potential fully, surface modification to increase its solubility is required.

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