Synthesis of Bacterial Oligosaccharides and Magnetic Glyconanoparticles for Potential Biological Applications

Das, Rituparna (2014) Synthesis of Bacterial Oligosaccharides and Magnetic Glyconanoparticles for Potential Biological Applications. PhD thesis, Indian Institute of Science Education and Research Kolkata.

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Abstract

Chapter 1 illustrates the significance of carbohydrates in various life processes, their applications in modern day therapeutics and the emergence of a new area of research called ‘glycomics’. Chapter 2 demonstrates the recent development in glycosylation strategies, the key to the synthetic carbohydrate chemistry. The main focus is given on the activation of glycosyl halides, thioglycosides and glycosyl trichloroacetimidates. Chapter 3 describes the total synthesis of the tetrasaccharide repeating unit of the O-antigen from Plesiomonas shigelloides in the form of its p-methoxyphenyl glycoside. Chapter 4 details the chemical synthesis of the tetrasaccharide repeating unit of the O-antigen from Edwardsiella tarda in the form of its p-methoxyphenyl glycoside. Chapter 5 illustrates the total synthesis of the pentasaccharide repeating unit of the O-antigen from Salmonella enterica O44 in the form of its p-methoxyphenyl glycoside. Chapter 6 deals with the design, synthesis and characterization of magnetic glyconanoparticles having Fe3O4 as the magnetic core and galactose, lactose, galabiose and globotriose as carbohydrate ligands.

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