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Abnormal NHC Palladium (II) Complex: An Active Catalyst for Cross-coupling reactions via Dehydrogenation

Prasannan, Sreejyothi (2016) Abnormal NHC Palladium (II) Complex: An Active Catalyst for Cross-coupling reactions via Dehydrogenation. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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    Abstract

    This thesis covers a general study on the dehydrogenative coupling of heteroarenes mainly using palladium (II) catalyst bearing abnormal NHC backbone. Through this work, we show that (aNHC)PdX dimer is a very active catalyst in dehydrogenative coupling reactions. It could activate the C–H bond of a wide range of heteroarenes, which include benzothiazole, benzoxazole, thiophene, furan, and N-methyl benzimidazole. Thus our catalyst is quite versatile in performing coupling reactions over a wide range of substrates. Further, it showed good activity even for a 1 mol% catalyst loading. Further, it exhibited good activity in the presence of different functional groups such as CN, CHO, Me, OMe, OAc, Cl etc., which is quite difficult to achieve with a single catalytic system. Apart from this it could achieve a good C-2 position selectivity in all the cases without compromising the yield. These promising results provide us confidence to proceed further with dehydrogenative heterocoupling reactions in the near future. These features promise a wide range of applications for (aNHC)PdX dimer in the field of bi-aryl synthesis. We look forward to exploiting these properties of our catalyst to enhance the synthesis of various drugs, enabling their commercial production in an economic and efficient manner.

    Item Type: Thesis (Masters)
    Additional Information: Supervisor: Dr. Swadhin K. Mandal
    Uncontrolled Keywords: Abnormal HC Palladium (II) Complex; Catalyst; Cross-coupling Reactions; Dehydrogenation; Heteroaromatic Biaryls; NHC Palladium (II) Complex
    Subjects: Q Science > QD Chemistry
    Divisions: Department of Chemical Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 16 Aug 2016 17:11
    Last Modified: 16 Aug 2016 17:12
    URI: http://eprints.iiserkol.ac.in/id/eprint/421

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