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Ring Opening Polymerization (ROP) of N-Carboxyanhydrides (NCAs) Using Amine Terminated Peptide Initiators

Parappurath, Akhil (2016) Ring Opening Polymerization (ROP) of N-Carboxyanhydrides (NCAs) Using Amine Terminated Peptide Initiators. Masters thesis, Indian Institute of Science Education and Research Kolkata.

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    Abstract

    In this report, we have synthesized sequence registered peptide-poly (γ-benzyl-L-glutamate) (PBLG) bio-conjugates via ring opening polymerization (ROP) of γ-benzyl-L-glutamate N-carboxyanhydride (PBLG-NCA) employing amine terminated peptide initiators, OMe-Leu-Val-Phe-NH₂ (Leu: Leucine; Val: Valine; Phe: Phenylalanine). In the first step, OMe-LVF-NH₂ was synthesized via solution phase methodology and thoroughly characterized by ¹H and ¹³C NMR and FT-IR characterization tools. In the next step, this amine terminated peptide was used as an initiator for ROP of BLG-NCA monomer at ambient condition.

    Item Type: Thesis (Masters)
    Additional Information: Supervisor: Dr. Priyadarsi De
    Uncontrolled Keywords: Amine Terminated Peptide Initiators; NCA; N-Carboxyanhydrides; Peptide Initiator; ROP; Ring Opening Polymerization
    Subjects: Q Science > QD Chemistry
    Divisions: Department of Chemical Sciences
    Depositing User: IISER Kolkata Librarian
    Date Deposited: 17 Aug 2016 10:37
    Last Modified: 17 Aug 2016 15:48
    URI: http://eprints.iiserkol.ac.in/id/eprint/422

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