Development of Palladium Nanocatalysts for Carbon-Carbon Coupling Reactions

Santra, Subhankar (2012) Development of Palladium Nanocatalysts for Carbon-Carbon Coupling Reactions. PhD thesis, Indian Institute of Science Education and Research Kolkata.

PDF (PhD thesis of Subhankar Santra) Subhankar_-Santra-Ph.D-Thesis.pdf - Submitted Version Restricted to Repository staff only Download (9MB)

Abstract

Carbon−carbon coupling reaction is broadly recognized as a reaction in which two different fragments are connected by a single C−C bond e.g., Suzuki, Heck, Sonogashira or Ullmann coupling reactions. The immense economic value of C-C coupling reaction in pharmaceutical industries has already been recognized with the award of Nobel Prize in Chemistry in 2010. The design, synthesis, and testing efficient catalysts for the C−C bond formation processes are part of the ongoing search to generate more competent and cost effective catalyst. Recent trend in this area considers the use of palladium nanoparticles (PdNPs) as a promising alternative for the search of milder catalysts under environmentally benign methods avoiding the use of noxious phosphine ligands. The high surface-to-volume ratio of the PdNPs having more active surface atoms compared to those of the bulk catalysts can promote C−C coupling reactions under milder condition. Furthermore, the use of solid supported heterogeneous PdNPs allows the development of “ligand-free” catalysis resulting in cost reduction, simplifying workup procedures and recycling the catalysts for a number of successive catalytic runs. The major objective of the present study is the development of recyclable palladium nanocatalysts for carrying out a number of C−C coupling reactions such as Ullmann coupling reaction, acyl Sonogashira reaction and Suzuki-Miyaura reaction under mild condition. This study emphasizes the development of palladium nanocatalysts aiming at the synthesis of important drug molecules with high recycling efficiency.

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