Chemical Synthesis of Biologically Active Bacterial Oligosaccharides

Pal, Debasish (2022) Chemical Synthesis of Biologically Active Bacterial Oligosaccharides. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Debasish Pal (17RS010)) 17RS010.pdf - Submitted Version Restricted to Repository staff only Download (38MB)

Abstract

The thesis is divided in the following five chapters. Chapter 1 illustrates the biological significance of carbohydrates in various life processes and therapeutic uses. Chapter 2 deals with the modern glycosylation techniques for stereoselective 1,2-cis glycosides in the domain of chemical O-glycosylation. Chapter 3 details the chemical synthesis of the pentasaccharide repeating unit of the Ospecific polysaccharide from Escherichia coli O132 in the form of its 2- aminoethyl glycoside. Chapter 4 illustrates chemical synthesis of β-L-rhamnose containing pentasaccharide repeating unit of the O-specific polysaccharide from a halophilic bacterium Halomonas ventosae RU5S2EL in the form of its 2-aminoethyl glycoside. Chapter 5 demonstrates the chemical synthesis of the trisaccharide repeating unit of the Oantigen from Pseudomonas putida BIM B-1100.

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