Fabrication of Foldamer Based Materials: Structure and Function

Maity, Suman Kumar (2013) Fabrication of Foldamer Based Materials: Structure and Function. PhD thesis, Indian Institute of Science Education And Research Kolkata.

PDF (PhD Thesis of Suman Kumar Maity) Suman-Kumar-Maity-PhD-Thesis.pdf - Submitted Version Restricted to Repository staff only Download (5MB)

Abstract

Molecular self-assembly is a spontaneous process where ordered structures are formed under thermodynamic and kinetic conditions as a consequence of specific and local interactions of molecules themselves through non covalent interactions including hydrogen bonding, electrostatic, hydrophobic, van der Waals, metal-ligand, and π-π stacking interaction. Selfassembling peptides can give rise to a variety of supramolecular architectures like supramolecular helix, supramolecular β-sheets and others, which have potential importance in chemical, biological as well as material sciences. So, the study of molecular self-assembly of synthetic building blocks is highly important. There are two types of self-assembly processes such as intermolecular and intramolecular. Generally intramolecular self assembly is referred to folding and the molecules are known as “Foldamers”. Self-assembling foldamers are one of the most attractive and useful building blocks in making various nanostructures including nanotubes, nanorods, nanovesicles, nanobelts, nanofibers and others because of their chemical diversity, biocompatibility, biodegradability and foldability into specific structures. The first step of foldamer design should impart the development of new molecular building blocks and fabricate designer backbones with well-defined secondary structural preferences using those building blocks. The main aim of this thesis is (1) to develop small amino acids based novel foldamers, (2) to study the self-assembly of foldamers into different supramolecualr architecture by noncovalent interaction such as hydrogen bonding interaction, hydrophobic interaction, π-π stacking interaction, (3) to decorate foldamer matrix with semiconductor nanoperticles and explore optoelectronic properties of the conjugates, (4) to study the non linear optical properties of the foldamers. Selective recognition and delivery of drug molecule is highly important in recent research.

Actions (login required)

View Item