Norbornene backbone containing antibacterial polymer

Mishra, Sugam (2022) Norbornene backbone containing antibacterial polymer. Masters thesis, Indian Institute of Science Education and Research Kolkata.

Text (MS dissertation of Sugam Mishra (17MS134)) 17MS134_Thesis_file.pdf - Submitted Version Restricted to Repository staff only Download (1MB)

Abstract

A random polymer containing Norbornene as a backbone to exert vigorous antibacterial activity was proposed. The polymer consists of three monomers: Monomer 1 contains a Glycine unit attached to a Norbornene derivative. The Glycine unit is liked with a 2000mg molecular weight Polyethylene glycol (PEG). The PEG unit enhances water solubility, inhibits bacteria growth, and imparts a biocompatibility effect to the polymer. For Monomer 2, a Norbornene derivative with an attached phenol group was synthesised. To this was attached 1, 5 dibromo pentane. The Br end in it would later be functionalised with triethylamine to give N⁺ unit, which exerts a strong membrane disrupting effect on the bacterial cell wall. Monomer 3 was designed with the same unit in the backbone as monomer 2, except that the side chain contained a Coumarin derivative instead of 1,5 dibromo pentane. Coumarin is an excellent bacterial membrane targeting agent & its fluorescence helps to keep track of the drug in Vivo. The Coumarin derivative was synthesized, but Monomer 3 couldn’t be synthesized. The synthesized compounds were all characterized by ¹H and ¹³C NMR spectroscopy. A compound with polymer properties and three side chains, each with individual antibacterial features, promises a solid & potent antibacterial combination.

Actions (login required)

View Item