Luminescent Ir(III)/Pt(II) Complexes: Biomolecule Binding, Cellular Imaging and Therapeutic Application

Das, Bishnu (2023) Luminescent Ir(III)/Pt(II) Complexes: Biomolecule Binding, Cellular Imaging and Therapeutic Application. PhD thesis, Indian Institute of Science Education and Research Kolkata.

Text (PhD thesis of Bishnu Das (18RS073)) 18RS073.pdf - Submitted Version Restricted to Repository staff only Download (26MB)

Abstract

This thesis explores the captivating world of luminescent Ir(III)/Pt(II) complexes, shedding light on their photophysical and electrochemical characteristics and delving into their special applications. Through meticulous investigation and analysis, this research aims to unravel the intricacies underlying the unique attributes of these complexes and provide insights into their potential in various scientific disciplines. The thesis contains six chapters that delve into different aspects of these complexes. Chapter 01 serves as an introduction, providing a comprehensive overview of the topic and establishing the foundation for the subsequent chapters. Chapter 02 explores trinuclear organometallic Pt-Ir-Pt complexes, delving into their photophysical properties, amino-acid binding, and protein sensing abilities. In Chapter 03, attention turns to a cyclometalated trinuclear Ir(III)/Pt(II) complex as a luminescent probe for histidine-rich proteins, offering insights into their interactions and potential for protein-related applications. Chapter 04 focuses on phosphorescent trinuclear Pt-Ir-Pt complexes, examining their photophysical and electrochemical properties and their interaction with the guanine nucleobase. In Chapter 05, the spotlight shifts to the tunability of organelle-specific imaging and photodynamic therapeutic efficacy using theranostic mono and trinuclear organometallic iridium(III) complexes. Finally, Chapter 06 explores the application of mono and trinuclear cyclometalated iridium(III) complexes in differential imaging and antimicrobial photodynamic therapy.

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