Gupta, Surbhi (2023) Visible Light-Induced 1,3-Thioheteroarylation of [1.1.1]Propellane. Masters thesis, Indian Institute of Science Education and Research Kolkata.
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Text (MS dissertation of Surbhi Gupta (18MS144))
Thesis_18MS144.pdf - Submitted Version Restricted to Repository staff only Download (1MB) |
Abstract
Herein we convey a straightforward strategy comprising a visible-light-induced radical cascade process to assemble 1-thio-3-heteroaryl bicyclo[1.1.1]pentane molecules which can act as bioisosteres in drug discovery to improve the pharmacokinetic properties of the drug candidates. This three-component protocol is completely metal- catalyst-free, in which quinoxaline-2(1H)-one itself acts as a sensitizer, making it unrivaled. A green solvent system and visible-light irradiation at low temperatures are adopted to unlock novel avenues in drug development.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Supervisor: Dr. Devarajulu Sureshkumar |
| Uncontrolled Keywords: | Bioisosteres; Drug Development; Drug Discovery; Pharmacokinetic; Propellane; Radical Cascade Process; Thioheteroarylation |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Department of Chemical Sciences |
| Depositing User: | IISER Kolkata Librarian |
| Date Deposited: | 05 Feb 2024 11:15 |
| Last Modified: | 05 Feb 2024 11:15 |
| URI: | http://eprints.iiserkol.ac.in/id/eprint/1581 |
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